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Subsequently, the cells were treated with BPTES (3 M, a glutaminase inhibitor that blocks the glutamine oxidation pathway), etomoxir (4 M, a CPT1A inhibitor, which is crucial for the transport of long-chain FAs from cytosol into mitochondria for oxidation), or UK5099 (2 M, an inhibitor of the glucose oxidation pathway that blocks the mitochondrial pyruvate carrier) successively, and oxygen consumption rate (OCR) was measured prior to and after the addition of each inhibitor
In addition, when Ive had an injury or another concern, Ive been able to go in and make a game plan with the team for pain management and overall improvement of my health
But the biological plausibility is sound, and some clinicians are incorporating this strategy into their long-term GLP-1 treatment plans
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